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王文奎,王峰,王 岭
《中国工程科学》 2007年 第9卷 第8期 页码 30-34
艾滋病是一种获得性免疫缺陷综合征,中医学的观点则是正气严重不足。正气依靠精神的支撑,而精神来源于饮食气味及其精微物质 ,精微物质的转化主要靠脏腑功能的正常运化。脏腑功能活动是生命运动的根本。五脏各有所主,各司其职,并且相互和合与平衡,只有当五 脏功能旺盛,并且相互和合时,人体的生命力才会强大,机体“正气”充足,才会有免疫力。在五脏之中,肝、脾、肾三脏功能要保持平衡, 其他各脏功能才会自然趋向平衡与协调,人体才会健康长寿,这就是“三维守恒”法则。
Monocyte subsets and their differentiation tendency after burn injury
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《医学前沿(英文)》 2013年 第7卷 第4期 页码 397-400 doi: 10.1007/s11684-013-0298-7
Monocytes are critical effectors and regulators of immune response. Studying the nomenclature of monocyte subsets may be beneficial for understanding the complex function of monocytes in steady and inflammatory states. A monocyte has the potential to differentiate into dendritic cells or macrophages, and this behavior significantly changes in severely burned patients and mice. The findings in the present study may help enhance understanding on the perturbation of the immune system after severe burn injury.
关键词: monocyte differentiation burn
GID complex regulates the differentiation of neural stem cells by destabilizing TET2
《医学前沿(英文)》 doi: 10.1007/s11684-023-1007-9
关键词: TET2 GID complex neural stem cells differentiation of neurons
Abivertinib inhibits megakaryocyte differentiation and platelet biogenesis
《医学前沿(英文)》 2022年 第16卷 第3期 页码 416-428 doi: 10.1007/s11684-021-0838-5
关键词: abivertinib Btk inhibitor platelet megakaryocyte megakaryopoiesis thrombopoiesis
The secondary laticifer differentiation in rubber tree is induced by trichostatin A, an inhibitor of
Shixin ZHANG,Shaohua WU,Weimin TIAN
《农业科学与工程前沿(英文)》 2016年 第3卷 第4期 页码 357-362 doi: 10.15302/J-FASE-2016125
关键词: Hevea brasiliensis histone acetylation laticifer differentiation trichostatin vascular cambia
Atypical manifestations of acute coronary syndrome — throat discomfort: a multi-center observational
《医学前沿(英文)》 2022年 第16卷 第4期 页码 651-658 doi: 10.1007/s11684-021-0859-0
关键词: acute coronary syndrome (ACS) throat discomfort (TD) throat pain cardiology departments non-cardiologic physicians
《环境科学与工程前沿(英文)》 2023年 第17卷 第3期 doi: 10.1007/s11783-023-1636-x
● Environmental parameters affected functional bacteria and network associations.
关键词: Activated sludge Bacterial community Tank-dependence Network association Functional bacteria
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《医学前沿(英文)》 2014年 第8卷 第4期 页码 419-426 doi: 10.1007/s11684-014-0383-6
Aneurysmal dilatation of the aortic sinuses of Valsalva has been most extensively documented in the setting of aortopathies, particularly Marfan syndrome. On the other hand, there is limited data in the literature about congenital sinus of Valsalva aneurysms outside this context. For the purpose of this review, we carried out a literature search on aneurysmal dilatation of the sinuses of Valsalva in Marfan syndrome, and compared this with congenital sinus of Valsalva aneurysms, also including data from a case series from our institution. In conclusion, there are differences in management of aortic dilatation in Marfan syndrome and congenital sinus of Valsalva aneurysms. Though less well-recognised, congenital aneurysms are often associated with significant morbidity and mortality and timely intervention is necessary.
关键词: sinus of Valsalva aneurysms Marfan syndrome aortic dissection
《工程管理前沿(英文)》 2023年 第10卷 第2期 页码 285-299 doi: 10.1007/s42524-022-0197-1
关键词: spatiotemporal differentiation industrial agglomeration low-carbon economy construction machinery industry empirical study
Cluster analysis for syndromes of real-world coronary heart disease with angina pectoris
Yufeng Zhao, Xueyun Yu, Xinyu Cao, Lin Luo, Liyun He, Shusong Mao, Li Ma, Peijing Rong, Yuxue Zhao, Guozheng Li, Baoyan Liu
《医学前沿(英文)》 2018年 第12卷 第5期 页码 566-571 doi: 10.1007/s11684-017-0556-1
Syndromes of coronary heart disease with angina pectoris were analyzed to provide guidance for clinical practice and to improve accuracy of traditional Chinese medicine (TCM) diagnoses and efficacy of TCM treatment. A total of 860 cases with coronary heart disease with angina pectoris were selected from TCM Clinical Research Information Sharing System for TCM clinics and research. Syndromes were automatically extracted with the cluster method and were analyzed to provide objective evidence for clinical studies. Final syndrome classifications were recognized and confirmed by clinical experts. Popular syndromes included Qi and blood deficiency, blood stasis and obstruction collaterals, liver depression and spleen deficiency, and Qi stagnation and blood stasis. Syndromes Qi and blood deficiency and blood stasis and obstruction collaterals accounted for 28.61% of total syndromes, whereas liver depression and spleen deficiency and Qi stagnation and blood stasis accounted for 26.44%. The main syndrome elements comprised Qi deficiency, blood deficiency, blood stasis, and Qi stagnation.
关键词: syndrome differentiation real-world study coronary heart disease with angina pectoris cluster analysis
Repression of CDKN2C caused by PML/RARα binding promotes the proliferation and differentiation block
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《医学前沿(英文)》 2016年 第10卷 第4期 页码 420-429 doi: 10.1007/s11684-016-0478-3
Inappropriate cell proliferation during oncogenesis is often accompanied by inactivation of components involved in the cell cycle machinery. Here, we report that cyclin-dependent kinase inhibitor 2C (CDKN2C) as a member of the cyclin-dependent kinase inhibitors is a target of the PML/RARα oncofusion protein in leukemogenesis of acute promyelocytic leukemia (APL). We found that CDKN2C was markedly downregulated in APL blasts compared with normal promyelocytes. Chromatin immunoprecipitation combined with quantitative polymerase chain reaction demonstrated that PML/RARα directly bound to the CDKN2C promoter in the APL patient-derived cell line NB4. Luciferase assays indicated that PML/RARα inhibited the CDKN2C promoter activity in a dose-dependent manner. Furthermore, all-trans retinoic acid treatment induced CDKN2C expression by releasing the PML/RARα binding on chromatin in NB4 cells. Functional studies showed that ectopic expression of CDKN2C induced a cell cycle arrest at the G0/G1 phase and a partial differentiation in NB4 cells. Finally, the transcriptional regulation of CDKN2C was validated in primary APL patient samples. Collectively, this study highlights the importance of CDKN2C inactivation in the abnormal cell cycle progression and differentiation block of APL cells and may provide new insights into the study of pathogenesis and targeted therapy of APL.
关键词: CDKN2C acute promyelocytic leukemia cell cycle arrest differentiation
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《医学前沿(英文)》 2018年 第12卷 第2期 页码 224-228 doi: 10.1007/s11684-017-0538-3
Bronchiolitis obliterans syndrome (BOS) after hematopoietic stem cell transplantation (HSCT) is a major cause of morbidity and mortality with limited treatment options. Lung transplantation (LTX) has been rarely reported as a treatment option for selected HSCT recipients with this problem. In the present study, we reported six patients who underwent LTX due to BOS after HSCT (two females, four males) from January 2012 to December 2014 in our center. The median time from HSCT to diagnosis of BOS was 2.5 years (ranging from 1 to 5 years). At a median time of 4 years (ranging from 2 to 5 years) after diagnosis of BOS, four patients received bilateral sequential LTX, and two patients received single LTX. One of the recipients suffered from mild acute rejection after LTX, another suffered from primary lung graft dysfunction on post-operation day 2, and three experienced fungal infections. The median time for follow-up after LTX was 19.5 months (ranging from 12 to 39 months). At present, all patients are alive with good functional capacity and no relapse of BOS and hematologic malignancy conditions. Patients who received bilateral LTX have better pulmonary functions than patients who received single LTX.
关键词: bronchiolitis obliterans syndrome (BOS) hematopoietic stem cell transplantation (HSCT) lung transplantation (LTX)
Genetic basis of adult-onset nephrotic syndrome and focal segmental glomerulosclerosis
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《医学前沿(英文)》 2017年 第11卷 第3期 页码 333-339 doi: 10.1007/s11684-017-0564-1
Nephrotic syndrome (NS) is one of the most common glomerular diseases with signs of nephrosis, heavy proteinuria, hypoalbuminemia, and edema. Dysfunction of glomerular filtration barrier causes protein loss through the kidneys. Focal segmental glomerulosclerosis (FSGS) accounts for nearly 20% of NS among children and adults. Adult-onset FSGS/NS is often associated with low response to steroid treatment and immunosuppressive medication and poor renal survival. Several genes involved in NS and FSGS have been identified by linkage analysis and next-generation sequencing. Most of these genes encode proteins and are highly expressed in glomerular podocytes, which play crucial roles in slit-diaphragm signaling, regulation of actin cytoskeleton dynamics and maintenance of podocyte integrity, and cell–matrix interactions. In this review, we focus on the recently identified genes in the adult-onset NS and FSGS and discuss clinical significance of screening of these genes.
关键词: nephrotic syndrome focal segmental glomerulosclerosis genetic
Cushing’s syndrome during pregnancy caused by adrenal cortical adenoma: a case report and literature
null
《医学前沿(英文)》 2015年 第9卷 第3期 页码 380-383 doi: 10.1007/s11684-015-0407-x
Cushing’s syndrome (CS) during pregnancy is a rare condition with significant maternal and fetal complications. A case of CS during the third trimester of pregnancy secondary to adrenocortical adenoma was reported. Literature review revealed the disadvantages of different treatments in this period. Besides the conservative treatment, surgery is recommended for CS during the third trimester of pregnancy secondary to adrenal adenoma, if an experienced surgeon is available.
Differential diagnosis of cervical nerve compression syndrome of the external intervertebral foramen
WANG Jinwu, NI Weifeng, XU Jianguang, ZHU Haibo, GUO Shangchun, ZENG Bingfang, ZHAO Binghui
《医学前沿(英文)》 2007年 第1卷 第2期 页码 177-180 doi: 10.1007/s11684-007-0033-3
关键词: satisfactory COX minimus operation compression syndrome
标题 作者 时间 类型 操作
The secondary laticifer differentiation in rubber tree is induced by trichostatin A, an inhibitor of
Shixin ZHANG,Shaohua WU,Weimin TIAN
期刊论文
Atypical manifestations of acute coronary syndrome — throat discomfort: a multi-center observational
期刊论文
Tank-dependence of the functionality and network differentiation of activated sludge community in a full-scale
期刊论文
Aneurysmal dilatation of the aortic sinuses of Valsalva — beyond Marfan syndrome: a single centre experience
null
期刊论文
coupling relationship of industrial agglomeration and low-carbon economy considering spatiotemporal differentiation
期刊论文
Cluster analysis for syndromes of real-world coronary heart disease with angina pectoris
Yufeng Zhao, Xueyun Yu, Xinyu Cao, Lin Luo, Liyun He, Shusong Mao, Li Ma, Peijing Rong, Yuxue Zhao, Guozheng Li, Baoyan Liu
期刊论文
Repression of CDKN2C caused by PML/RARα binding promotes the proliferation and differentiation block
null
期刊论文
Lung transplantation for bronchiolitis obliterans syndrome after allogenic hematopoietic stem cell transplantation
null
期刊论文
Cushing’s syndrome during pregnancy caused by adrenal cortical adenoma: a case report and literature
null
期刊论文